Title of article
A new potent inhibitor of fungal melanin biosynthesis identified through combinatorial chemistry
Author/Authors
Lee D. Jennings، نويسنده , , Zdzislaw Wawrzak، نويسنده , , Denise Amorose، نويسنده , , Rand S. Schwartz، نويسنده , , Douglas B. Jordan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2509
To page
2514
Abstract
A new fungicide lead has been identified by in vitro screening of a focused combinatorial library. Amides (768) were synthesized in pools of four and assayed as inhibitors of scytalone dehydratase. Deconvolution of one of the most active pools led to the discovery of a potent inhibitor of the enzyme 3b (Ki = 26 pM), which has fungicidal properties.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790376
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