Title of article
Dysidiolide and related γ-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25
Author/Authors
Jill L. Blanchard، نويسنده , , David M. Epstein، نويسنده , , Michael D. Boisclair، نويسنده , , Johannes Rudolph، نويسنده , , Kollol Pal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
2
From page
2537
To page
2538
Abstract
Synthetic dysidiolide, as well as several related compounds containing a γ-hydroxybutenolide moiety, were tested in in vitro Cdc25 assays against both synthetic and natural substrates. Contrary to literature values which are in the low micromolar range, we observe only millimolar inhibitory activity for these compounds versus Cdc25 phosphatase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790381
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