Fecal excretion pattern of bile acids in rats fed high fat diets and neomycin in induced colon tumorigenesis

Neomycin augments colon tumorigenesis in 1,2-dimethylhydrazine treated rats fed polyunsaturated fat diet and decreases fecal cholic acid excretion, while it inhibits tumorigenesis with increased cholic acid and decreased deoxycholic acid excretions in rats fed high cholesterol diet. Participation of other fecal bile acids seems to be insignificant in relation to colon carcinogenesis.