Title of article
Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor
Author/Authors
Kim Y. Avenell، نويسنده , , Izzy Boyfield، نويسنده , , Michael S. Hadley، نويسنده , , Christopher N. Johnson، نويسنده , , David J. Nash، نويسنده , , Graham J. Riley، نويسنده , , Geoffrey Stemp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2715
To page
2720
Abstract
A novel series of 5,6,7,8-tetrahydroquinazolines, 4,5,6,7-tetrahydroindazoles and 4,5,6,7-tetrahydrobenzothiazoles has been prepared, having high affinity and selectivity for the dopamine D3 receptor. The 4-methoxy-5,6,7,8-tetrahydroquinazoline 6i and 2-amino-4,5,6,7-tetrahydrobenzothiazole 8 proved to be agonists with among the highest D3 receptor affinities and selectivities reported to date.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790412
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