Title of article
Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors
Author/Authors
Jeffrey H. Toney، نويسنده , , Kelly A. Cleary، نويسنده , , Gail G. Hammond، نويسنده , , Xiling Yuan، نويسنده , , Walter J. May، نويسنده , , Steven M. Hutchins، نويسنده , , Wallace T. Ashton، نويسنده , , Dana E. Vanderwall، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2741
To page
2746
Abstract
Resistance to carbapenem antibiotics in Gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-β-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3-n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-β-lactamases as well as renal dehydropeptidase I to a lesser extent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790417
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