Title of article
Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework
Author/Authors
Nan-Horng Lin، نويسنده , , Melwyn A. Abreo، نويسنده , , David E. Gunn، نويسنده , , Suzanne A. Lebold، نويسنده , , Edmund L. Lee، نويسنده , , James T. Wasicak، نويسنده , , Ann-Marie Hettinger، نويسنده , , Jerome F. Daanen، نويسنده , , David S. Garvey، نويسنده , , Jeffrey E. Campbell، نويسنده , , James P. Sullivan، نويسنده , , Michael Williams، نويسنده , , Stephen P. Arneric، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2747
To page
2752
Abstract
Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to> 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](−) cytisine from whole rat brain synaptic membranes).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790418
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