Title of article
Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors
Author/Authors
Michael R. Becker، نويسنده , , William R. Ewing، نويسنده , , Roderick S. Davis، نويسنده , , Henry W. Pauls، نويسنده , , Cuong Ly، نويسنده , , Aiwen Li، نويسنده , , Helen J. Mason، نويسنده , , Yong Mi Choi-Sledeski، نويسنده , , Alfred P. Spada، نويسنده , , Valeria Chu، نويسنده , , Karen D. Brown، نويسنده , , Dennis J. Colussi، نويسنده , , Robert J. Leadley، نويسنده , , Ross Bentley، نويسنده , , Jeff Bostwick، نويسنده , , Charles Kasiewski، نويسنده , , Suzanne Morgan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2753
To page
2758
Abstract
Thienopyridine sulfonamide pyrrolidinones were found to be potent and selective inhibitors of the coagulation cascade enzyme factor Xa. SAR studies led to several compounds that were selected for further in vivo investigation. These novel aryl binding pocket moieties represent a structural modification to a series of fXa inhibitors. Several compounds proved to be efficacious iv antithrombotic agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790419
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