Title of article
Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs
Author/Authors
Akira Asai، نويسنده , , Satoru Nagamura، نويسنده , , Eiji Kobayashi، نويسنده , , Katsushige Gomi، نويسنده , , Hiromitsu Saito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2995
To page
2998
Abstract
The water-soluble duocarmycin B1 prodrugs such as glycoside 3, phosphate 4 and carbamate 5 were synthesized for improving biological and pharmaceutical profiles of duocarmycin. Among these prodrugs, N-methylpiperazinylcarbamoyl derivative 5 exhibited potent antitumor activity against several human tumors in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790467
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