Title of article
Conformationally restricted paclitaxel analogues: Macrocyclic mimics of the “hydrophobic collapse” conformation
Author/Authors
Thomas C. Boge، نويسنده , , Zhijun Wu، نويسنده , , Richard H. Himes، نويسنده , , David G. Vander Velde، نويسنده , , Gunda I. Georg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3047
To page
3052
Abstract
Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3′-phenyl group and the 2-benzoate moiety with two-atom tethers to mimic the “hydrophobic collapse” paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790478
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