Title of article
Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative
Author/Authors
Yoshiki Yoshida، نويسنده , , Keiji Matsuda، نويسنده , , Hiroshi Sasaki، نويسنده , , Yoshimi Matsumoto، نويسنده , , Satoru Matsumoto، نويسنده , , Hisashi Takasugi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
3123
To page
3126
Abstract
The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790492
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