Title of article
The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives
Author/Authors
David G. Smith، نويسنده , , Andrew D. Gribble، نويسنده , , David Haigh، نويسنده , , Robert J. Ife، نويسنده , , Patrick Lavery، نويسنده , , Peter Skett، نويسنده , , Brian P. Slingsby، نويسنده , , Rachel Stacey، نويسنده , , Robert W. Ward، نويسنده , , Andrew-West، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3137
To page
3142
Abstract
Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC50 14–60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790495
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