Title of article
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1 and 5-HT re-uptake ligands
Author/Authors
Monique B. van Niel، نويسنده , , Margaret S. Beer، نويسنده , , JoséL. Castro، نويسنده , , Susan K. F. Cheng، نويسنده , , David C. Evans، نويسنده , , Anne Heald، نويسنده , , Laure Hitzel، نويسنده , , Peter Hunt، نويسنده , , Russell Mortishire-Smith، نويسنده , , Desmond OʹConnor، نويسنده , , Alan P. Watt، نويسنده , , Angus M. MacLeod، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3243
To page
3248
Abstract
A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT1 and serotonin re-uptake receptors which shows excellent pharmacokinetic parameters.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790515
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