Title of article
Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors
Author/Authors
Shinichiro Ono، نويسنده , , Shigeki Kuwahara، نويسنده , , Masahiro Takeuchi، نويسنده , , Hiroshi Sakashita، نويسنده , , Youichiro Naito، نويسنده , , Takao Kondo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3285
To page
3290
Abstract
We report the syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Among the compounds we evaluated, 1,5-Bis[4-(5-amidinobenzofuran-2-ylcarbonyl)piperazinylcarbonylmethoxy]cyclooctane 26 (AY0068) was found to be a selective and potent non-peptide inhibitor. 26 was effective in PCA reaction in rats without showing antihistaminic activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790523
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