• Title of article

    Antiplatelet actions of aporphinoids from formosan plants

  • Author/Authors

    Yi-Chen Chia، نويسنده , , Keh-Shaw Chen، نويسنده , , Ya-Ling Chang، نويسنده , , Che-Ming Teng، نويسنده , , Yang-Chang Wu، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1999
  • Pages
    6
  • From page
    3295
  • To page
    3300
  • Abstract
    Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 μM against AA-induced platelet aggregation. Abstract Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 μM against AA-induced platelet aggregation.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1999
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    790525

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790525