Title of article
Antitumor agents 201.1 Cytotoxicity of harmine and β-carboline analogs
Author/Authors
Junko Ishida، نويسنده , , Hui-Kang Wang، نويسنده , , Kenneth F. Bastow، نويسنده , , Chang-Qi Hu، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3319
To page
3324
Abstract
Twenty-six β-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. α-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3–1.2 μg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790529
Link To Document