Title of article
N-Phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter
Author/Authors
K. R. C. Prakash، نويسنده , , Amir P. Tamiz، نويسنده , , Gian Luca Araldi، نويسنده , , Mei Zhang، نويسنده , , Kenneth M. Johnson، نويسنده , , Alan P. Kozikowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
3325
To page
3328
Abstract
A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5-HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790530
Link To Document