Title of article
Synthesis and biological activity of a novel series of indole-derived PPARγ agonists
Author/Authors
Brad R. Henke، نويسنده , , Kimberley K. Adkison، نويسنده , , Steven G. Blanchard، نويسنده , , Lisa M. Leesnitzer، نويسنده , , Robert A. Mook Jr.، نويسنده , , Kelli D. Plunket، نويسنده , , John A. Ray، نويسنده , , Claudia Roberson، نويسنده , , Rayomand Unwalla، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3329
To page
3334
Abstract
The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator-activated receptor gamma (PPARγ) are reported. These new analogs are selective for PPARγ vs the other PPAR subtypes, and the most potent compounds in this series are comparable to in vitro potencies at PPARγ reported for the thiazolidinedione-based antidiabetic drugs currently in clinical use.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790531
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