Title of article
Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
Author/Authors
Ta-i Honda، نويسنده , , BarbieAnn V. Rounds، نويسنده , , Lothar Bore، نويسنده , , Frank G. Favaloro Jr.، نويسنده , , Gordon W. Gribble، نويسنده , , Nanjoo Suh، نويسنده , , Yongping Wang، نويسنده , , Michael B. Sporn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3429
To page
3434
Abstract
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-γ in mouse macrophages.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790549
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