Title of article
6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase
Author/Authors
John E. Kerrigan، نويسنده , , Matthew C. Walters، نويسنده , , Kerri J. Forrester، نويسنده , , Jason B. Crowder، نويسنده , , Lisa J. Christopher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
27
To page
30
Abstract
A study of various 2-[(alkylsulfonyl)oxy]-6-substituted-1H-isoindole-1,3-dionesʹ inhibition of chymotrypsin compared to inhibition of HLE reveals that acylamino substitution in the 6-position increases selectivity and potency of these inhibitors for HLE. The best HLE inhibitor in this series was 6-(methylglutaryl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione with a kobs/[I]=220,000 M−1 s−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790564
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