Title of article
The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family
Author/Authors
Thomas R. Webb، نويسنده , , Neli Melman، نويسنده , , Dmitriy Lvovskiy، نويسنده , , Xiao-duo Ji، نويسنده , , Kenneth A. Jacobson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
31
To page
34
Abstract
Pharmacophore queries from previously known potent selective A3 antagonists were generated by Chem-X. These queries were used to search a pharmacophore database of diverse compounds (CNS-SetTM). In vitro assays of 186 ‘hits’ yielded over 30 active compounds, for four adenosine receptor subtypes. This search strategy may also be applicable to the discovery of new ligands via receptor homology data.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790565
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