Title of article
Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
Author/Authors
Cheol Kyu Han، نويسنده , , Soon Kil Ahn، نويسنده , , Nam Song Choi، نويسنده , , Ryung Kee Hong، نويسنده , , Seung Kee Moon، نويسنده , , Hyoung Sik Chun، نويسنده , , Sang Joon Lee، نويسنده , , Jung Woo Kim، نويسنده , , Chung Il Hong، نويسنده , , Deukjoon Kim، نويسنده , , Jeong Hyeok Yoon، نويسنده , , Kyoung Tai No، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
39
To page
43
Abstract
New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790567
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