Title of article
Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate
Author/Authors
Ke Xu، نويسنده , , Paul J. Thornalley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
53
To page
54
Abstract
N-(N′-Phenethylthiocarbamoyl) derivatives of sphingosine and sphinganine were prepared. They had antitumour activity: GC50 values of 0.64±0.02 μM (N=18) and 1.6±0.01 μM (N=18), respectively, with human leukaemia 60 cells in vitro. This antitumour effect may contribute to the suppression of carcinogenesis associated with dietary phenethyl isothiocyanate and sphingolipid bases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790569
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