Title of article
Structure–activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor
Author/Authors
Tianbao Lu، نويسنده , , Richard M. Soll، نويسنده , , Carl R. Illig، نويسنده , , Roger Bone، نويسنده , , Larry Murphy، نويسنده , , John Spurlino، نويسنده , , F. Raymond Salemme، نويسنده , , Bruce E. Tomczuk، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
79
To page
82
Abstract
The structure–activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790576
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