Title of article
Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from α-amino acids
Author/Authors
Michelle Groarke، نويسنده , , Basil Hartzoulakis، نويسنده , , M. Anthony McKervey، نويسنده , , Brian Walker، نويسنده , , Carvell H. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
153
To page
155
Abstract
The reductive amination of an amino acid derived glyoxal, with the free amino group of a protected amino acid or oligopeptide fragment, has been developed as a simple and efficient method for the preparation of ketomethylene amino pseudo-oligopeptide isosteres AaΨ(COCH2NH)Aa. Trichlorosilane–DMF is the reagent of choice for the reduction.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790592
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