Title of article
Structure–activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors
Author/Authors
Yoshio Hayashi، نويسنده , , Kiyoko Iijima، نويسنده , , Jun Katada، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
199
To page
201
Abstract
Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790603
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