Title of article
N-(Sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor
Author/Authors
James J. McNally، نويسنده , , Mark A. Youngman، نويسنده , , Timothy W. Lovenberg، نويسنده , , Diane H. Nepomuceno، نويسنده , , Sandy J. Wilson، نويسنده , , Scott L. Dax، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
213
To page
216
Abstract
[3a,4,5,9b-Tetrahydro-1H-benzo[e]indol-2-yl]amines were prepared via reductive amination and concomitant cyclization of α-cyanomethyl-β-aminotetralins. N-acylation with Ω-sulfonamido-carboxylic acids and subsequent reduction afforded a series of N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines, which bound to the human neuropeptide Y Y5 receptor with nanomolar affinity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790606
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