Title of article
Amido-(propyl and allyl)-hydroxybenzamidines: development of achiral inhibitors of factor Xa
Author/Authors
Yong Gong، نويسنده , , Henry W. Pauls، نويسنده , , Alfred P. Spada، نويسنده , , Mark Czekaj، نويسنده , , Guyan Liang، نويسنده , , Valeria Chu، نويسنده , , Dennis J. Colussi، نويسنده , , Karen D. Brown، نويسنده , , Jingbo Gao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
217
To page
221
Abstract
The design, synthesis and SAR of amido-(propyl and allyl)-hydroxybenzamidine coagulation factor Xa inhibitors is described. These achiral inhibitors are selective for fXa vis a vis structurally related serine proteases and are readily prepared in 6–7 linear steps. The most potent member 9j (fXa Ki=0.75 nM) is selective (>1000-fold) and an effective anticoagulant in mammalian plasma.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790607
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