Title of article
Recognition and inhibition of HIV integrase by a novel dinucleotide
Author/Authors
Michael Taktakishvili، نويسنده , , Nouri Neamati، نويسنده , , Yves Pommier، نويسنده , , Vasu Nair، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
249
To page
251
Abstract
The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually novel dinucleotide, pIsodApdC, which is a potent inhibitor of this key viral enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790614
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