Title of article
Synthesis and study of a new adenine–acridine tandem, inhibitor of exonuclease III
Author/Authors
Philippe Belmont، نويسنده , , Martine Demeunynck، نويسنده , , Jean-François Constant، نويسنده , , Jean Lhomme، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
293
To page
295
Abstract
A new heterodimer adenine-chain-acridine containing a mixed amido-guanidinium linker chain was synthesized. To achieve the synthesis a new method of introduction of aminoalkyl chain at position 9 of adenine was designed. The heterodimer interacts specifically with the abasic sites in DNA and inhibits the major base excision repair enzyme in Escherichia coli, Exonuclease III.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790625
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