Title of article
Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides
Author/Authors
Thomas F. Walsh، نويسنده , , Richard B. Toupence، نويسنده , , Jonathan R. Young، نويسنده , , Song X. Huang، نويسنده , , Feroze Ujjainwalla، نويسنده , , Robert J. DeVita، نويسنده , , Mark T. Goulet، نويسنده , , Matthew J. WyvrattJr.، نويسنده , , Michael H. Fisher، نويسنده , , Jane-Ling Lo، نويسنده , , Ning Ren، نويسنده , , Joel B. Yudkovitz، نويسنده , , Yi Tien Yang، نويسنده , , Kang Cheng، نويسنده , , Roy G. Smith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
443
To page
447
Abstract
SAR studies which focused upon the C-6 position of a recently described series of quinolone gonadotropin releasing hormone antagonists are reported. Synthetic access to diverse quinolone-6-carboxamides was achieved via the palladium-catalyzed amino-carbonylation reactions of iodide Scheme 1 and Scheme 2 with various amines. Amides related to 9y were especially potent, functional antagonists of rat and human GnRH receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790660
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