Title of article
Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data
Author/Authors
Der-Ing Liao، نويسنده , , Gregory S. Basarab، نويسنده , , Anthony A. Gatenby، نويسنده , , Douglas B. Jordan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
491
To page
494
Abstract
Compounds that control rice blast, but not other crop diseases, were selected for testing as inhibitors of trihydroxynaphthalene reductase of the fungal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (Ki=25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex was determined at 2.1 Å resolution.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790671
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