Title of article
Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives
Author/Authors
Geoffrey Wells، نويسنده , , Tracey D. Bradshaw، نويسنده , , Patrizia Diana، نويسنده , , Angela Seaton، نويسنده , , Dong-Fang Shi، نويسنده , , Andrew D. Westwell، نويسنده , , Malcolm F. G. Stevens، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
513
To page
515
Abstract
The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790676
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