Title of article
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity
Author/Authors
Conrad Kunick، نويسنده , , Christiane Schultz، نويسنده , , Thomas Lemcke، نويسنده , , Daniel W. Zaharevitz، نويسنده , , Rick Gussio، نويسنده , , Ravi K. Jalluri، نويسنده , , Edward A. Sausville، نويسنده , , Maryse Leost، نويسنده , , Laurent Meijer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
567
To page
569
Abstract
9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790688
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