1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2

Novel 1,3-diarylcycloalkanopyrazoles Scheme 1 and Scheme 2, and diphenyl hydrazides Scheme 1 and Scheme 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in Scheme 1 and Scheme 2 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in Scheme 1 and Scheme 2 are also separated by three atoms. SAR of both phenyl rings in Scheme 1 and Scheme 2, and the aliphatic ring in Scheme 1 and Scheme 2 will be discussed. Scheme 1. Scheme 2.