Title of article
Synthesis of a novel class of cdc25A inhibitors from vitamin D3
Author/Authors
Kosuke Dodo، نويسنده , , Masato Takahashi، نويسنده , , Yuji Yamada، نويسنده , , Yoshikazu Sugimoto، نويسنده , , Yuichi Hashimoto، نويسنده , , Ryuichi Shirai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
615
To page
617
Abstract
We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative Figure 1 and Scheme 1 strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells.
Figure 1.
Scheme 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790698
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