Title of article
Novel retinoic acid receptor α agonists: syntheses and evaluation of pyrazole derivatives
Author/Authors
Kouichi Kikuchi، نويسنده , , Shigeki Hibi، نويسنده , , Hiroyuki Yoshimura، نويسنده , , Kenji Tai، نويسنده , , Takayuki Hida، نويسنده , , Naoki Tokuhara، نويسنده , , Toshihiko Yamauchi، نويسنده , , Mitsuo Nagai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
619
To page
622
Abstract
We have designed and synthesized a series of pyrazole derivatives as candidate retinoic acid receptor (RAR) agonists. One of them, 4-[5-(1, 5-diisopropyl-1H-3-pyrazolyl)-1H-2-pyrrolyl]benzoic acid (11b), which possesses a 2,5-disubstituted pyrrole moiety, showed selective transactivation activity for the RARα receptor, and had highly potent cell-differentiating activity on HL-60 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790699
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