Title of article
Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor α agonists
Author/Authors
Shigeki Hibi، نويسنده , , Katsuya Tagami، نويسنده , , Kouichi Kikuchi، نويسنده , , Hiroyuki Yoshimura، نويسنده , , Kenji Tai، نويسنده , , Takayuki Hida، نويسنده , , Naoki Tokuhara، نويسنده , , Toshihiko Yamauchi، نويسنده , , Mitsuo Nagai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
623
To page
625
Abstract
Synthesis and structure–activity relationships (SAR) of RARα-selective agonists are discussed. 4-[5-(5,8-Dimethyl-2H-3-chromenyl)-1H-2-pyrrolyl]benzoic acid (12a), which possesses a flat structural moiety and an oxygen atom at the hydrophobic part, showed highly selective transactivation activity at the RARα receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790700
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