Title of article
Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties
Author/Authors
Wang-Qing Liu، نويسنده , , Michel Vidal، نويسنده , , Christophe Mathé، نويسنده , , Christian Perigaud، نويسنده , , Christiane Garbay، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
669
To page
672
Abstract
Phosphopeptide prodrugs bearing two S-acyl-2-thioethyl (SATE) biolabile phosphate protections were developed. They are capable to inhibit the Shc/Grb2 interaction and MAP kinases (ERK1 and ERK2) phosphorylation in cellular assay. The S-acetyl-2-thioethyl (MeSATE) analogue showed an IC50 of 1 μM in the inhibition of the colony formation of tumor cell line NIH3T3/HER2.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790711
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