Title of article
Conversion of a polysaccharide to nitric oxide-releasing form. dual-mechanism anticoagulant activity of diazeniumdiolated heparin
Author/Authors
Joseph E. Saavedra، نويسنده , , Daniel L. Mooradian، نويسنده , , Kelly A. Mowery، نويسنده , , Mark H. Schoenfisch، نويسنده , , Michael L. Citro، نويسنده , , Keith M. Davies، نويسنده , , Mark E. Meyerhoff، نويسنده , , Larry K. Keefer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
751
To page
753
Abstract
We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790728
Link To Document