Title of article
Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue improves the 3′-exonuclease stability of 2′-5′-oligoadenylate-antisense conjugates
Author/Authors
Jeroen C. Verheijen، نويسنده , , Anne-Marie M. van Roon، نويسنده , , Nico J. Meeuwenoord، نويسنده , , Hanneke R. Stuivenberg، نويسنده , , Suzanne F. Bayly، نويسنده , , Ling Chen، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Paul F. Torrence، نويسنده , , Jacques H. van Boom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
801
To page
804
Abstract
Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue at the 3′-terminus of DNA or 2-5A-DNA sequences resulted in a significantly enhanced 3′-exonuclease resistance while the affinity for complementary RNA was only slightly decreased. Furthermore, the binding to and activation of human RNase L by thus modified 2-5A-DNA conjugates was not altered as compared to the parent unmodified 2-5A-DNAs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790740
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