Title of article
Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives
Author/Authors
Richard F. Clark، نويسنده , , Zhenkun Ma، نويسنده , , Sanyi Wang، نويسنده , , George Griesgraber، نويسنده , , Michael Tufano، نويسنده , , Hong Yong، نويسنده , , Leping Li، نويسنده , , Xiaolin Zhang، نويسنده , , Angela M. Nilius، نويسنده , , Daniel T. W. Chu، نويسنده , , Yat Sun Or، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
815
To page
819
Abstract
A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790743
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