Title of article
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src
Author/Authors
Martin Missbach، نويسنده , , Eva Altmann، نويسنده , , Leo Widler، نويسنده , , Mira u a، نويسنده , , Elisabeth Buchdunger، نويسنده , , Helmut Mett، نويسنده , , Thomas Meyer، نويسنده , , Jonathan Green، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
945
To page
949
Abstract
5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50<50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790770
Link To Document