Title of article
Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors
Author/Authors
Damian O. Arnaiz، نويسنده , , Zuchun (Spring) Zhao، نويسنده , , Amy Liang، نويسنده , , Lan Trinh، نويسنده , , Marc Whitlow، نويسنده , , Sunil K. Koovakkat، نويسنده , , Kenneth J. Shaw، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
957
To page
961
Abstract
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790773
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