• Title of article

    β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2

  • Author/Authors

    Peter M. Brophy، نويسنده , , Alison M. Campbell، نويسنده , , Annamaria J. van Eldik، نويسنده , , Paul H. Teesdale-Spittle، نويسنده , , Eva Liebau، نويسنده , , Meng F. Wang، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2000
  • Pages
    3
  • From page
    979
  • To page
    981
  • Abstract
    A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2000
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    790778

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790778