Title of article
Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists
Author/Authors
Robert E. Boyd، نويسنده , , John R. Carson، نويسنده , , Ellen E. Codd، نويسنده , , A. Diane Gauthier، نويسنده , , Lou Anne Neilson، نويسنده , , Sui-Po Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1109
To page
1111
Abstract
A series of 4-diarylaminotropanes has been prepared. Both endo and exo diastereomeric forms bound to the delta opioid receptor but the endo isomers were more potent and selective versus the μ opioid receptor than the exo isomers. The most potent delta opioid agonist (14) exhibited a delta opioid Ki of 0.2 nM and was 860-fold selective over mu.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790811
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