Title of article
Phosphate prodrugs of PD154075
Author/Authors
Zhijian Zhu، نويسنده , , Huai-Gu Chen، نويسنده , , Om P. Goel، نويسنده , , O. Helen Chan، نويسنده , , Linda A. Stilgenbauer، نويسنده , , Barbra H. Stewart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1121
To page
1124
Abstract
In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD154075 (compound 9) with significantly increased aqueous solubility, sufficient stability in aqueous solution and good bio-reconversion in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790814
Link To Document