Title of article
Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules
Author/Authors
Wuyi Wang، نويسنده , , Patrice Préville، نويسنده , , Nicolas Morin، نويسنده , , Samir Mounir، نويسنده , , Weizhong Cai، نويسنده , , M. Arshad Siddiqui، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1151
To page
1154
Abstract
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure–activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790821
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