Title of article
Carbacyclic peptide mimetics as VCAM–VLA-4 antagonists
Author/Authors
Jefferson Tilley، نويسنده , , Gerry Kaplan، نويسنده , , Nader Fotouhi، نويسنده , , Barry Wolitzky، نويسنده , , Karen Rowan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1163
To page
1165
Abstract
Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of ‘carba’ analogues. Potency in the VCAM–VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790824
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