Title of article
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4′-side chain analogues
Author/Authors
Kumiko Takeuchi، نويسنده , , Todd J. Kohn، نويسنده , , Richard W. Harper، نويسنده , , Ho-Shen Lin، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Michael E. Richett، نويسنده , , Daniel J. Sall، نويسنده , , Gerry F. Smith، نويسنده , , Minsheng Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1199
To page
1202
Abstract
Novel benzo[b]thiophene diamine thrombin inhibitors were investigated, focusing on a contracted C4′-side chain series. SAR studies identified compounds with either a pyrrolidino or morpholino group as potent, active site directed thrombin inhibitors when the amino group was connected to the C3-phenyl ring with a methylene linker at the C4′ position of the phenyl ring.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790832
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