Title of article
A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors
Author/Authors
Takashi Owa، نويسنده , , Tatsuo Okauchi، نويسنده , , Kentaro Yoshimatsu، نويسنده , , Naoko Hata Sugi، نويسنده , , Yoichi Ozawa، نويسنده , , Takeshi Nagasu، نويسنده , , Nozomu Koyanagi، نويسنده , , Tadashi Okabe، نويسنده , , Kyosuke Kitoh، نويسنده , , Hiroshi Yoshino، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1223
To page
1226
Abstract
A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790838
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